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TMPH-02819
|
Otoraplin Protein, Mouse, Recombinant (His)
Melanoma inhibitory activity-like protein,Otoraplin...
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Mouse
|
P. pastoris (Yeast)
|
|
Otoraplin Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 14.0 kDa and the accession number is Q9JIE3. |
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TMPY-03280
|
RAMP3 Protein, Human, Recombinant (hFc)
receptor (G protein-coupled) activity modifying pro...
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Human
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HEK293 Cells
|
|
RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. They are required to transp... |
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TMPJ-01137
|
MIA Protein, Human, Recombinant (His)
MIA,Melanoma Inhibitory Activity Protein,Melanoma-D...
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Human
|
E. coli
|
|
Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au... |
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TMPY-00008
|
CXCL1 Protein, Rat, Recombinant
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulatin...
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Rat
|
E. coli
|
|
CXCL1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is P14095. |
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TMPY-02805
|
GNGT1 Protein, Human, Recombinant (His)
guanine nucleotide binding protein (G protein), γ transducin...
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Human
|
E. coli
|
|
GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the ... |
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TMPY-00433
|
CXCL1 Protein, Mouse, Recombinant
Gro1,Scyb1,gro,KC,Fsp,N51,chemokine (C-X-C motif) ligand 1 (...
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Mouse
|
E. coli
|
|
CXCL1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is A2RTH0. |
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TMPY-02180
|
CXCL1 Protein, Human, Recombinant (His & NusA)
CA21H,CPS1,CYP21,GRO1,GROa,SCYB1,NAP-3,MGSA-a,P450c21B,CAH1,...
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Human
|
E. coli
|
|
CXCL1 Protein, Human, Recombinant (His & NusA) is expressed in E. coli expression system with His and NusA tag. The predicted molecular weight is 65 kDa and the accession number is P09341-1. |
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TMPH-01056
|
Caspase-3 Protein, Human, Recombinant (His)
SCA-1,Protein Yama,CASP-3,Cysteine protease CPP32,CPP32,SREB...
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Human
|
E. coli
|
|
Caspase-3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.6 kDa and the accession number is P42574. |
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TMPY-02026
|
CXCL1 Protein, Human, Recombinant (His & SUMO)
FSP,P450c21B,CYP21B,CAH1,GROa,SCYB1,MGSA,chemokine (C-X-C mo...
|
Human
|
E. coli
|
|
CXCL1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with His and SUMO tag. The predicted molecular weight is 21.3 kDa and the accession number is P09341-1. |
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TMPY-02868
|
CXCL1 Protein, Human, Recombinant
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulatin...
|
Human
|
E. coli
|
|
CXCL1 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 7.9 kDa and the accession number is P09341-1. |
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TMPJ-00011
|
CXCL2 Protein, Mouse, Recombinant
Gro-beta,GRO β,GROB,melanoma growth stimulatory activity...
|
Mouse
|
E. coli
|
|
C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 shares approximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is induced by PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the hum... |
|
TMPY-01061
|
FGF-10 Protein, Human, Recombinant
fibroblast growth factor 10,KGF2
|
Human
|
E. coli
|
|
Fibroblast growth factor 10 (FGF10) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. FGF10 pla... |
|
TMPY-02078
|
HtrA2/Omi Protein, Human, Recombinant (His)
PARK13,OMI,HtrA serine peptidase 2,PRSS25
|
Human
|
E. coli
|
|
Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor... |
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TMPJ-01470
|
SCF Protein, Human, Recombinant
Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac...
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Human
|
E. coli
|
|
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. |
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TMPJ-00051
|
IL-3 Protein, Mouse, Recombinant (His)
Mast cell growth factor,Il3,Multipotential colony-stimulatin...
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Mouse
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HEK293 Cells
|
|
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, bu... |
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TMPY-01897
|
PRSS3 Protein, Human, Recombinant (His)
PRSS4,TRY4,TRY3,RP11-176F3.3,T9,MTG,protease, serine 3
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Human
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HEK293 Cells
|
|
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ... |
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TMPH-01031
|
CAPN2 Protein, Human, Recombinant (His)
Calpain-2 catalytic subunit,Millimolar-calpain,Calpain-2 lar...
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Human
|
E. coli
|
|
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. CAPN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82... |
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TMPJ-01462
|
IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
IL15,IL15RA&IL15,IL-15,Interleukin-15,IL-15 Receptor α & IL-...
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Human
|
HEK293 Cells
|
|
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... |
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TMPK-00639
|
Alkaline Phosphatase (Germ type) /ALPG Protein, Rat, Recombinant (His)
GCAP,ALP-1,Alkaline Phosphatase,ALPPL2,PLAP-like,ALPPL,ALPG,...
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Rat
|
HEK293 Cells
|
|
Alkaline phosphatase can be considered "our favorite enzyme" for reasons apparent to those who diagnose and treat metabolic bone diseases or who study skeletal biology. Few might know, however, that alkaline phosphatase likely represents the most frequently assayed enzyme in all of medicine. Elevated activity in the circulation is universally recognized as a marker for skeletal or hepatobiliary disease. Alkaline Phosphatase (Germ type) /ALPG Protein, Rat, Recombinant (His) is expressed in HEK293... |
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TMPY-03382
|
FGF-6 Protein, Human, Recombinant
HBGF-6,HST2,fibroblast growth factor 6
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Human
|
E. coli
|
|
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF6 plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis. It is also required for normal muscle regeneration. FGF6 gene d... |
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TMPY-04552
|
AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,...
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Human
|
Baculovirus Insect Cells
|
|
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... |
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TMPJ-01099
|
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece...
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Human
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HEK293 Cells
|
|
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun... |
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TMPJ-00412
|
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,Vascular perme...
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Human
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HEK293 Cells
|
|
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... |
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TMPK-00474
|
IL-22RA1 Protein, Cynomolgus, Recombinant (His)
CRF2-9,IL22R1,IL-22R-α-1,IL-22RA1,zcytoR11,IL22R,IL-22R-alph...
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Cynomolgus
|
HEK293 Cells
|
|
IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activatio... |
|
TMPY-04483
|
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...
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Human
|
Baculovirus Insect Cells
|
|
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... |
|
TMPY-03118
|
ORM2 Protein, Human, Recombinant (His)
AGP-B',ORM2,orosomucoid 2,AGP-B,AGP2
|
Human
|
HEK293 Cells
|
|
ORM2 belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. Lipocalins can be found in gram-negative bacteria, vertebrate cells, and invertebrate cells, and plants. They are associated with many biological processes. ORM2 functions as a transport protein in the bloodstream. It is expressed by the liver and s... |
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TMPY-04125
|
PTP1B Protein, Human, Recombinant (His)
protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN...
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Human
|
E. coli
|
|
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p... |
|
TMPJ-00059
|
IL-7 Protein, Human, Recombinant (His)
Interleukin-7,IL7,白细胞介素,IL-7,白介素
|
Human
|
HEK293 Cells
|
|
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe... |
|
TMPY-00672
|
Azurocidin/CAP37 Protein, Human, Recombinant (His)
AZU,NAZC,azurocidin 1,hHBP,AZAMP,HUMAZUR,CAP37,HBP,AZU1
|
Human
|
HEK293 Cells
|
|
Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is n... |
|
TMPY-03407
|
NQO1 Protein, Human, Recombinant (His)
NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...
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Human
|
E. coli
|
|
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex... |
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TMPY-02929
|
ENTPD2 Protein, Human, Recombinant (aa 29-460, His)
ectonucleoside triphosphate diphosphohydrolase 2,NTPDase-2,R...
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Human
|
Baculovirus Insect Cells
|
|
NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii in... |
|
TMPY-02603
|
STAT6 Protein, Human, Recombinant (His)
STAT6C,IL-4-STAT,STAT6B,signal transducer and activator of t...
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Human
|
Baculovirus Insect Cells
|
|
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators... |
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TMPY-01460
|
ABHD4 Protein, Human, Recombinant (His)
abhydrolase domain containing 4,ABH4
|
Human
|
Baculovirus Insect Cells
|
|
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain containing (ABHD) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. The alpha/beta-hydrolase 4 (ABH4) is a lysophospholipase/phospholipa... |
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TMPY-03650
|
BirA Protein, E. coli, Recombinant (His & MBP)
BirA,dhbB,bioR
|
E. coli
|
E. coli
|
|
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these proteins to be tetramerized by binding to streptavidin. Because of the specificity of the biotinylation at the C terminus, the orientation of the membrane proteins on the streptavidin is equivalent to that of the native protein on the cell surface. These tetrameric proteins can be use... |
|
TMPY-00117
|
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16
|
Human,Cynomolgus
|
Baculovirus Insect Cells
|
|
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... |
|
TMPY-02115
|
R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)
CRISTIN1,THSD2,R-spondin 3,PWTSR
|
Human
|
HEK293 Cells
|
|
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s... |
|
TMPJ-01204
|
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1...
|
Human
|
HEK293 Cells
|
|
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... |
|
TMPY-02585
|
Acid sphingomyelinase/SMPD1 Protein, Mouse, Recombinant (His)
aSMase,ASM,Zn-SMase,A-SMase,sphingomyelin phosphodiesterase ...
|
Mouse
|
Baculovirus Insect Cells
|
|
Sphingomyelin phosphodiesterase 1 (SMPD1) , also known as ASM ( acid sphingomyelinase ), is a member of the acid sphingomyelinase family of enzymes. Three isoforms have been identified, isoform 1 is 631 amino acids (aa) in length as the pro form, while Isoform 2 and isoform 3 have lost catalytic activity. The active SMPD1 isoform 1 contains one saposin B-type domain that likely interacts with sphingomyelin, and a catalytic region. Human SMPD1 is 86% aa identical to mouse SMPD1. SMPD1 is a monome... |
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TMPY-01355
|
Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)
G-α-h,HEL-S-45,TGC,transglutaminase 2,TG2,GNAH,G-ALPHA-h
|
Human
|
Baculovirus Insect Cells
|
|
Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase that also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which... |
|
TMPY-02707
|
PAH Protein, Human, Recombinant (415 Asn/Asp, His)
phenylalanine hydroxylase,PH,PKU1,PKU
|
Human
|
Baculovirus Insect Cells
|
|
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg... |
|
TMPJ-00994
|
LTBR Protein, Mouse, Recombinant (hFc)
Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept...
|
Mouse
|
HEK293 Cells
|
|
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs... |
|
TMPY-00203
|
LOXL2 Protein, Mouse, Recombinant (His)
1110004B06Rik,4930526G11Rik,9430067E15Rik,lysyl oxidase-like...
|
Mouse
|
HEK293 Cells
|
|
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act... |
|
TMPJ-01065
|
Noggin/NOG Protein, Mouse, Recombinant (His)
Nog,Noggin
|
Mouse
|
HEK293 Cells
|
|
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mouse Noggin cDNA encodes a 232 amino acid (aa) residue precursor protein with 19 aa residue putative signal peptide that is cleaved to generate the 213 aa residue mature protein which is secreted as a homodimeric glycoprotein. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affi... |
|
TMPY-02062
|
SULT1A1 Protein, Human, Recombinant (His)
HAST1/HAST2,PST,P-PST,ST1A1,STP,sulfotransferase family, cyt...
|
Human
|
E. coli
|
|
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Pa... |
|
TMPY-01736
|
COX-2 Protein, Human, Recombinant (His)
GRIPGHS,PHS-2,hCox-2,COX-2,PGHS-2,prostaglandin-endoperoxide...
|
Human
|
Baculovirus Insect Cells
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PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression ... |
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TMPY-06981
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IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ...
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Human
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E. coli
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IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage... |
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TMPJ-01011
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FGF-9 Protein, Mouse, Recombinant (His)
heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f...
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Mouse
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E. coli
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Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v... |
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TMPY-03431
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HDAC4 Protein, Human, Recombinant (aa 612-1084)
histone deacetylase 4,HA6116,HDAC-4,HD4,BDMR,HDAC-A,AHO3,HDA...
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Human
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Baculovirus Insect Cells
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HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th... |
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TMPY-02869
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MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12
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Human
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E. coli
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Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... |
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TMPY-02700
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BCL2 Protein, Human, Recombinant (His)
Bcl-2,PPP1R50,B-cell CLL/lymphoma 2
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Human
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E. coli
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BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins... |
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