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JNK-1-IN-3 (Compound 9e) 作为一种JNK1抑制剂,该化合物可以有效地降低JNK1的基因表达,抑制其磷酸化蛋白质水平,并减少肿瘤中其下游靶标c-Jun与c-Fos的表达,同时恢复p53的活性。此外,JNK-1-IN-3 在抑制肾癌和乳腺癌细胞系的增殖上显示出较高效能,展现了其在体内外的抗癌潜力。
JNK-1-IN-3 (Compound 9e) 作为一种JNK1抑制剂,该化合物可以有效地降低JNK1的基因表达,抑制其磷酸化蛋白质水平,并减少肿瘤中其下游靶标c-Jun与c-Fos的表达,同时恢复p53的活性。此外,JNK-1-IN-3 在抑制肾癌和乳腺癌细胞系的增殖上显示出较高效能,展现了其在体内外的抗癌潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | JNK-1-IN-3 (Compound 9e) acts as a JNK1 inhibitor, both reducing JNK1 gene expression and lowering the protein levels of its phosphorylated form. It concurrently diminishes the expression of downstream targets c-Jun and c-Fos in tumors, while also restoring p53 activity. Exhibiting broad-spectrum antiproliferative effects, JNK-1-IN-3 is particularly effective against renal and breast cancer cell lines, showing significant anticancer activity both in vivo and in vitro. |
分子量 | 368.36 |
分子式 | C19H17FN4O3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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