T-91825

Name: T-91825
Brand: TargetMol
SKU: T37966
Rating: 4.5 (1 reviews)

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产品编号 T37966Cas号 189345-04-8

T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].

T-91825

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产品编号 T37966Cas号 189345-04-8

规格	价格	库存	数量
5 mg	询价	期货
10 mg	询价	期货

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产品介绍

生物活性

产品描述	T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].
体外活性	PPI-0903M is very active against S. aureus (MIC50=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC50=1 μg/mL)[1].PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC50s ranging from 0.25 to 4 μg/mL[1].
体内活性	AK-599 (20 mg/kg; s.c. three times a day for 2 days) decreases the bacterial cell counts in lungs more than 99.9% in a mouse pneumonia model caused by MRSA[2].

化学信息

分子量	604.69
分子式	C₂₂H₂₀N₈O₅S₄
CAS No.	189345-04-8

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (165.37 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6537 mL	8.2687 mL	16.5374 mL	82.6870 mL
5 mM	0.3307 mL	1.6537 mL	3.3075 mL	16.5374 mL
10 mM	0.1654 mL	0.8269 mL	1.6537 mL	8.2687 mL
20 mM	0.0827 mL	0.4134 mL	0.8269 mL	4.1343 mL
50 mM	0.0331 mL	0.1654 mL	0.3307 mL	1.6537 mL
100 mM	0.0165 mL	0.0827 mL	0.1654 mL	0.8269 mL