Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.

在生理浓度下，内源性神经类固醇Tetrahydrodeoxycorticosterone (THDOC) 选择性地增强αβδ受体介导的顿挫电流[1]。在海马体中，通过增强顿挫αβδ受体电流，可观察到神经元兴奋性的减少，这一效果通过使用10 nM Tetrahydrodeoxycorticosterone达到。值得注意的是，在丘脑皮层神经元中，虽然100 nM Tetrahydrodeoxycorticosterone可增强顿挫电流，但使用10 nM Tetrahydrodeoxycorticosterone并未观察到同样的效果[1]。

在肝性脑病(HE)的小鼠中，由于肝脏受到毒性伤害，如果脑组织中Tetrahydrodeoxycorticosterone (THDOC)的浓度足够，可在同种动物中诱导镇静作用[2]。