CDK4/6-IN-7

Name: CDK4/6-IN-7
Brand: TargetMol
SKU: T61738
Rating: 4.5 (1 reviews)

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产品编号 T61738Cas号 2649120-20-5

CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].

CDK4/6-IN-7

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产品编号 T61738Cas号 2649120-20-5

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品描述	CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for breast cancer research [1].
体外活性	CDK4/6-IN-7 (compound 7c) (0.1-656.1 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC 50 of 0.92 μM [1]. Cell Proliferation Assay [1] Cell Line: MCF-7 cells Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7, 656.1 μM Incubation Time: 48 hours Result: Inhibited MCF-7 cells growth, with an IC 50 of 0.92 μM.
体内活性	CDK4/6-IN-7 (compound 7c) (50 mg/kg; p.o. once daily for 7d) strongly reduces tumor growth rates in MCF-7 tumor-bearing mice [1]. Animal Model: Female nude mice (5 weeks) bearing MCF-7 tumor [1] Dosage: 50 mg/kg Administration: Oral gavage once daily for 7 days Result: Inhibited tumor growth with the tumor inhibition rate of 57.68% and was well tolerated.