Leu-AMS

Name: Leu-AMS
Brand: TargetMol
SKU: T11840
Price: 413 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T11840Cas号 288591-93-5

Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1.

Leu-AMS

还可以

产品编号 T11840Cas号 288591-93-5

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1.
靶点活性	LRS:22.34 nM
体外活性	Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all.?Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation[1].Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM.?Leu-AMS is highly cytotoxic in both cancer cells and normal cells.

化学信息

分子量	459.48
分子式	C₁₆H₂₅N₇O₇S
CAS No.	288591-93-5
密度	1.83 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 49.17 mg/mL (107.01 mM)

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.1764 mL	10.8819 mL	21.7637 mL	108.8187 mL
5 mM	0.4353 mL	2.1764 mL	4.3527 mL	21.7637 mL
10 mM	0.2176 mL	1.0882 mL	2.1764 mL	10.8819 mL
20 mM	0.1088 mL	0.5441 mL	1.0882 mL	5.4409 mL
50 mM	0.0435 mL	0.2176 mL	0.4353 mL	2.1764 mL
100 mM	0.0218 mL	0.1088 mL	0.2176 mL	1.0882 mL