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Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用,这可能涉及抑制肺部炎症过程。它具有胃保护活性,归因于减少 NO 产生和调节促炎细胞因子,抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分,通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。
Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用,这可能涉及抑制肺部炎症过程。它具有胃保护活性,归因于减少 NO 产生和调节促炎细胞因子,抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分,通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 353 | 现货 | |
5 mg | ¥ 828 | 现货 | |
10 mg | ¥ 1,330 | 现货 | |
25 mg | ¥ 2,230 | 现货 | |
50 mg | ¥ 3,330 | 现货 | |
100 mg | ¥ 4,770 | 现货 |
产品描述 | 1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may involve the inhibition of pulmonary inflammatory process. 3. Tetrahydrocoptisine has gastroprotective activity, is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-κB expression. 4. Tetrahydrocoptisine is an active anti-inflammatory constituent by inhibition of TNF-α, IL-6 and NO production possibly via down-regulation of NF-κB activation, phospho-ERK1/2 and phospho-p38MAPK signal pathways. |
别名 | 人血草碱, STYLOPINE |
分子量 | 323.34 |
分子式 | C19H17NO4 |
CAS No. | 4312-32-7 |
Smiles | C1Oc2cc3CCN4Cc5c6OCOc6ccc5CC4c3cc2O1 |
密度 | 1.47g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 4.17 mg/mL (12.89 mM), Sonication is recommended. | ||||||||||||||||||||
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