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IGF2R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P11717.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 29,000 | 期货 |
生物活性 | Immobilized TROP-2 Protein, Human, Recombinant (His) (Cat#TMPY-01262) at 2 μg/mL (100 μL/well) can bind IGF2R Protein, Human, Recombinant (hFc) (Cat#TMPY-07125), with a linear range of 0.16-4.0 μg/mL. |
产品描述 | IGF2R Protein, Human, Recombinant (hFc) is expressed in HEK293 Cells. The accession number is P11717. |
种属 | Human |
表达系统 | HEK293 Cells |
标签 | C-hFc |
蛋白编号 | P11717 |
蛋白构建 | A DNA sequence encoding the Human Igf2r (P11717) (Met1-Asp1365) was expressed with the Fc region of human IgG1 at the C-terminus. |
蛋白纯度 | ≥ 90% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. |
分子量 | 173.22 kDa (predicted); 196.1 kDa (reducing contition, due to glycosylation) |
内毒素 | < 1.0 EU per μg of the protein as determined by the LAL method |
缓冲液 | Lyophilized from sterile PBS, 8% Glycerol, 5% Trehalose, 0.02% Tween 80, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
复溶方法 | Please refer to the lot-specific COA. |
存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 | In general, Lyophilized powders are shipping with blue ice. |
研究背景 | Among IGFs, insulinlike growth factor 2 (IGF2) is a key regulator of cell growth, survival, migration and differentiation. The type 2 IGF receptor (IGF2R) modulates circulating and tissue levels of IGF2 by targeting it to lysosomes for degradation. The extracytoplasmic region of IGF2R has three binding sites: one for IGF2 in domain 11 and two for Man-6-P in domains 3, 5 and 9. Binding between IGF2 and IGF2R induces the lysosomal degradation of IGF2. IGF2R serves to clear IGF2 from the circulation or degrade excess circulating IGF2. Soluble IGF2R can affect the size of some organs exclusively by reducing the biological activity of IGF2. |
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