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Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II.
Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 |
产品描述 | Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. |
靶点活性 | RNA polymerase I:40.9±11.0 μM (Ki), RNA polymerase I:38.0±6.47 μM (Ki) |
体外活性 | Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1]. |
别名 | Thio-ITP, 6-Thio-ITP, 6-Thioinosine 5′-triphosphate, 6-Mercaptopurine-riboside-5'-triphosphate |
分子量 | 524.23 |
分子式 | C10H15N4O13P3S |
CAS No. | 27652-34-2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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