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5-HT2CR agonist 1 (compound 8) 为7-氯类似物,具有选择性地作为5-HT2CR部分激动剂作用(Emax=71.09%),其EC50值为121.5 nM。该化合物未显示出对5-HT2AR或5-HT2BR的活性。此外,5-HT2CR agonist 1未能募集β-arrestin活性,并在10 μM浓度下对hERG显示出较低的抑制效果。
5-HT2CR agonist 1 (compound 8) 为7-氯类似物,具有选择性地作为5-HT2CR部分激动剂作用(Emax=71.09%),其EC50值为121.5 nM。该化合物未显示出对5-HT2AR或5-HT2BR的活性。此外,5-HT2CR agonist 1未能募集β-arrestin活性,并在10 μM浓度下对hERG显示出较低的抑制效果。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | The compound 5-HT2CR agonist 1 (compound 8), a 7-chloro analogue, is a selective partial agonist for the 5-HT2C receptor, exhibiting an Emax of 71.09% and an EC50 of 121.5 nM, with no activity observed toward 5-HT2A or 5-HT2B receptors. It does not recruit β-arrestin and shows low hERG inhibition at 10 μM [1]. |
靶点活性 | 5-HT 2C Receptor:121.5 nM (EC 50 ) |
分子量 | 235.71 |
分子式 | C13H14ClNO |
CAS No. | 1216074-15-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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