PDGFRB Protein, Rat, Recombinant (hFc)

产品编号 TMPY-03474

PDGFRB Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number is Q05030.

PDGFRB Protein, Rat, Recombinant (hFc)

产品编号 TMPY-03474

PDGFRB Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number is Q05030.

规格	价格	库存	数量
100 μg	¥ 3,170	5日内发货

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产品信息

生物活性	1.Measured by its binding ability in a functional ELISA. 2. Immobilized mouse PDGF-B at 10μg/mL (100μL/well) can bind rat PDGFRB-Fc, the EC50 of rat PDGFRB-Fc is 0.02-0.2 μg/mL.
产品描述	PDGFRB Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number is Q05030.
种属	Rat
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q05030
别名	platelet-derived growth factor receptor, β polypeptide,platelet-derived growth factor receptor, beta polypeptide
蛋白构建	A DNA sequence encoding the rat PDGFRB (Q05030) (Met1-Lys530) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 32
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	83.2 kDa (predicted); 117 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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