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Perfluoroenanthic acid (Perfluoroheptanoic acid) 作为一种全氟烷基物质 (PFAS),在妊娠期对小鼠子代暴露时,会影响其精管的发育和睾丸中的m6A RNA甲基化,从而干扰精子生成并引起生殖毒性。此外,该化合物还能在初级皮层神经元的培养中改变树突棘的形态以及突触的形成,增强神经活动与突触传递,并提升兴奋性突触相关蛋白Synaptophysin和PSD95的表达水平。
Perfluoroenanthic acid (Perfluoroheptanoic acid) 作为一种全氟烷基物质 (PFAS),在妊娠期对小鼠子代暴露时,会影响其精管的发育和睾丸中的m6A RNA甲基化,从而干扰精子生成并引起生殖毒性。此外,该化合物还能在初级皮层神经元的培养中改变树突棘的形态以及突触的形成,增强神经活动与突触传递,并提升兴奋性突触相关蛋白Synaptophysin和PSD95的表达水平。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 待询 | 10-14周 | |
50 mg | 待询 | 10-14周 |
产品描述 | Perfluoroenanthic acid (Perfluoroheptanoic acid) is a perfluoroalkyl substance (PFAS) that negatively impacts spermatogenic development and testicular m6A RNA methylation in offspring exposed during gestation, thus impeding spermatogenesis and inducing reproductive toxicity. Additionally, in primary cortical neuron cultures, Perfluoroenanthic acid alters dendritic spine morphology and synaptogenesis, enhances neural activity and synaptic transmission, and increases the expression of excitatory synapse-associated proteins Synaptophysin and PSD95. |
别名 | 全氟庚酸, Tridecafluoroheptanoic acid, PFHpA, Perfluoroheptanoic acid |
分子量 | 364.06 |
分子式 | C7HF13O2 |
CAS No. | 375-85-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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