- 全部删除
- 您的购物车当前为空
DHFR-IN-22 (Compound 8) 是一种2,4-二氨基嘧啶类DHFR (Dihydrofolate Reductase)抑制剂,具有显著抑制分离的DHFR酶和主要的非结核分枝杆菌 (NTM) 种类(Mycobacterium avium和Mycobacterium abscessus)的活性。该化合物对M. abscessus的IC50为1.1 nM,MIC为1.5 μg/mL,对M. avium的IC50为6.3 nM,MIC为0.1 μg/mL,而对人源DHFR的IC50为2100 nM。DHFR-IN-22 有潜力用于探索抗NTM感染的新策略。
DHFR-IN-22 (Compound 8) 是一种2,4-二氨基嘧啶类DHFR (Dihydrofolate Reductase)抑制剂,具有显著抑制分离的DHFR酶和主要的非结核分枝杆菌 (NTM) 种类(Mycobacterium avium和Mycobacterium abscessus)的活性。该化合物对M. abscessus的IC50为1.1 nM,MIC为1.5 μg/mL,对M. avium的IC50为6.3 nM,MIC为0.1 μg/mL,而对人源DHFR的IC50为2100 nM。DHFR-IN-22 有潜力用于探索抗NTM感染的新策略。
产品描述 | DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor that falls under the category of 2,4-diaminopyrimidine compounds. It demonstrates significant inhibitory activity against isolated DHFR enzyme and major nontuberculous mycobacteria (NTM) species, specifically Mycobacterium avium and Mycobacterium abscessus. The compound has an IC50 of 1.1 nM and a MIC of 1.5 μg/mL for M. abscessus, and an IC50 of 6.3 nM and a MIC of 0.1 μg/mL for M. avium, while its IC50 for human DHFR is 2100 nM. DHFR-IN-22 may be promising for developing new strategies to combat NTM infections. |
分子量 | 414.5 |
分子式 | C22H30N4O4 |
CAS No. | 2941327-87-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
评论内容