Pim-1 kinase inhibitor 1 can be used in cancer research, showing anticancer activity against a variety of cancer cell lines by promoting cell apoptosis. Pim-1 kinase inhibitor 1 is an inhibitor of Pim-1 kinase with an IC 50 value of 0.11 μM [1].

Pim-1 kinase inhibitor 1 (0-200 μM; 24 h) shows vitro cytotoxic activity to several cancer cells and affects cell apoptosis [1]. Cell Cytotoxicity Assay [1] Cell Line: MCF-7, CACO, HepG-2, HCT-116 and WI-38 cells Concentration: 0-200 μM Incubation Time: 24 hours Result: Exhibited vitro cytotoxic activity to MCF-7, CACO, HepG-2, HCT-116 and WI-38 cell lines with IC 50 s of 10.93, 4.91, 7.01, 3.41 and 27.181 μM, respectively. Promoted apoptosis by increasing Casp-3, BAX and Bcl-2 concentration to achieve anti-cancer activity.