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Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂,IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募,进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。
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Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂,IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募,进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 523 | 现货 | |
2 mg | ¥ 743 | 现货 | |
5 mg | ¥ 1,070 | 现货 | |
10 mg | ¥ 1,720 | 现货 | |
25 mg | ¥ 2,970 | 现货 | |
50 mg | ¥ 4,650 | 现货 | |
100 mg | ¥ 6,520 | 现货 | |
500 mg | ¥ 12,800 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,180 | 现货 |
产品描述 | Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity. |
分子量 | 414.47 |
分子式 | C25H23FN4O |
CAS No. | 2290527-07-8 |
Smiles | Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1 |
密度 | 1.299 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 25 mg/mL (60.32 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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