CCR2 Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is P41597-2.

Human

HEK293 Cells

PCLUD,MCP-1-R,FLJ78302,CMKBR2,CKR2B,CKR2A,CKR2,CD192,CCR2B,CCR2A,CCR-2,CC-CKR-2

A DNA sequence encoding the Human CCR2 (P41597-2) (Met1-Phe328,thermostabilizing mutations) was expressed with a flag tag at the N-terminus.

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

The C-C motif chemokine receptor-2 (CCR2) is a G protein-coupled receptor (GPCR), made up of a carboxy-terminus, extracellular amino terminus, and a hydrophobic transmembrane domain consisting of 7 amino acid segments that mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. CCR2 is expressed on monocytes, immature dendritic cells, and T-cell subpopulations, and mediates their migration towards endogenous CCL2. CCR2 is necessary for macrophage-dependent inflammatory responses and the development of atherosclerosis. In mice, CCR2 deficiency reduced macrophage content, increased adiponectin expression, ameliorated hepatic steatosis, and improved systemic glucose homeostasis and insulin sensitivity. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. Furthermore, CCR2 mRNA was highly expressed in prostate cancer (PCa) metastatic tissues compared with benign prostate tissues according to real-time RT-PCR3, suggesting that CCR2 may contribute to PCa development.