神经系统疾病

The CNS-MPO Library represents a subset of compounds from ChemBridge’s stock of more than 1.3 million lead-like and drug-like small molecule screening compounds representing a wide range of different chemotypes.

数量多：含3万种潜在活性小分子化合物，是 CNS 疾病相关研究的有力工具；

2154 种与神经退行性疾病相关的化合物，可用于高通量和高内涵筛选；

1246 种神经系统相关、结构新颖的化合物；

1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；

2540 种CNS 相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

509 个 CNS-Penetrant 生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

268 种生物活性小分子化合物，用于高通量、高内涵筛选；

193 种特异靶向肾上腺素受体的生物活性小分子化合物的集合，是相关疾病药物筛选的有效工具；

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channel Blocker library (657 compounds in total) was designed as a special screening library containing compounds with predicted HCN channels blocking activity and selectivity.

5-hydroxytryptamine agonist general library in Otava contains 199 compounds

GSK3BETA Focused Library in the Princeton BioMolecal Research contains 544 compounds.

Life Chemicals has designed its Caspase Targeted Library using docking-based virtual screening. Caspase Targeted Library contains 2800 compounds.

CNS BBB Screening Library for the new CNS targets discovery: 23,000 compounds

524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；

Beta secretase 1 (BACE1) inhibitor library in Otava contains 342 compounds

The CNS Diversity Pre-Plated Set comprises almost 6055 structurally diverse, potentially CNS-penetrant compounds.

Cathepsin B targeted library in Otava contains 275 compounds

OTAVAchemicals offers a 5-HT1B Receptor Targeted Library (1,836 compounds in total) designed with the receptor-based virtual screening of pre-filtered compound library docked in orthosteric and extended pockets of the 5-HT1B ligand-binding site. This lib

Acetylcholine nicotinic agonist library in Otava contains 269 compounds

BACE库包含7171个化合物。

CNS-permeable Compounds Library in UORSY contains 10651 compounds.

Acetylcholinesterase (AChE) targeted library in Otava contains 828 compounds

MAO B inhibitor library in Otava contains 182 compounds

5-hydroxytryptamine antagonist general library in Otava contains 290 compounds

We offer Alzheimer's Disease Targeted Polypharmacology Library (631 compounds in total), which is a special screening library that contains compounds with predicted inhibitory activity against both AChE and BACE-1.

Anticonvulsant library in Otava contains 1830 compounds

GSK3 inhibitors might also have the potential for neurodegenerative disorders, such as Alzheimer's disease. Glycogen synthase kinase 3 (GSK3) inhibitor library contains 479 compounds.

OTAVAchemicals offers Catechol O‑Methyl Transferase (COMT) Targeted Library.

OTAVAchemicals offers Nicotinic Acetylcholine Receptor Targeted Library (640 compounds).

Antipsychotic library in Otava contains 1315 compounds

We also offer a library of small molecular compounds, optimized for researchers focused on diseases of the central nervous system, 60100-molecules big, our CNS library was optimized to only include compounds with predicted high blood-brain barrier penetra

CNS Library contains 120883 compounds

The CNS Macrocycles Library comprises almost 1122 structurally diverse, potentially CNS-penetrant compounds.

ChemBridge has identified a subset of more than 3,000 macrocyclic compounds from its Macrocycle Library predicted to have a high probability of good blood-brain barrier penetration based on an MPO scoring approach.

This library contains about 2,000 compounds with physicochemical properties preferable for BBB penetration and simultaneously suitable for oral administration.

857 种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；

986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；

Library of compounds acting on central nervous system (CNS) targets

672 种与神经元分化相关的化合物，可以用于神经系统疾病药物研发

Life Chemicals has designed its original Phosphodiesterase PDE10 Screening Library by combining different computational approaches to develop a unique method for in silico search of small-molecule screening compounds with potential PDE10 inhibitory activity.

Antimigraine library in Otava contains 426 compounds

Life Chemicals has prepared a novel Library of more than 1,000 structurally diverse drug-like screening compounds of potential NMDA channel blockers

5-hydroxytryptamine 1A antagonist library in Otava contains 600 compounds

Antidepressant library in Otava contains 1554 compounds

It is patently obvious that CNS activity (and trans-cellular permeability in general) is a complex function of physical chemical properties of molecules such as size, lipophilicity, hydrogen-bonding potential, charge, and conformation.

Cathepsin T targeted library in Otava contains 1550 compounds

We offer the Cathepsin K Targeted Library. It contains 761 compounds with predicted inhibitory activity against this protease and is suitable for the early stage of drug discovery.