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顶部生物活性储存和溶解信息计算器

(±)16(17)-EpDPA

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产品编号 T37235Cas号 155073-46-4
别名 (±)16,17-epoxy DPA, (±)16,17-epoxy Docosapentaenoic Acid, (±)16,17-EpDPE, (±)16,17 EDP, (±)16(17)-EpDPA

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]

(±)16(17)-EpDPA
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(±)16(17)-EpDPA

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产品编号 T37235 别名 (±)16,17-epoxy DPA, (±)16,17-epoxy Docosapentaenoic Acid, (±)16,17-EpDPE, (±)16,17 EDP, (±)16(17)-EpDPACas号 155073-46-4

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]

规格价格库存数量
25 μg
¥ 2,180
35日内发货
50 μg
¥ 3,450
35日内发货
100 μg
¥ 5,500
35日内发货
500 μg
¥ 15,300
35日内发货
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生物活性
产品描述
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]
别名(±)16,17-epoxy DPA, (±)16,17-epoxy Docosapentaenoic Acid, (±)16,17-EpDPE, (±)16,17 EDP, (±)16(17)-EpDPA
化学信息
分子量344.495
分子式C22H32O3
CAS No.155073-46-4
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 50 mg/mL (145.14 mM), Sonication is recommended.
DMF: 50 mg/mL (145.14 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.9 mM), Sonication is recommended.
Ethanol: 50 mg/mL (145.14 mM), Sonication is recommended.
溶液配制表
PBS (pH 7.2)/DMSO/DMF/Ethanol
1mg5mg10mg50mg
1 mM2.9028 mL14.5140 mL29.0280 mL145.1400 mL
DMSO/DMF/Ethanol
1mg5mg10mg50mg
5 mM0.5806 mL2.9028 mL5.8056 mL29.0280 mL
10 mM0.2903 mL1.4514 mL2.9028 mL14.5140 mL
20 mM0.1451 mL0.7257 mL1.4514 mL7.2570 mL
50 mM0.0581 mL0.2903 mL0.5806 mL2.9028 mL
100 mM0.0290 mL0.1451 mL0.2903 mL1.4514 mL

SCI 文献

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， TargetMol | Animal experiments 一共给药动物 10 只 ，您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL 。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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关键词

16(17)-EpDPA16,17 EDP16,17-epoxy Docosapentaenoic Acid(±)16(17) EpDPA16,17-EpDPE(±)16(17)EpDPA16,17-epoxy DPA

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