PD-L1 Protein, Human, Recombinant (His), PE-Labeled

产品编号 TMPY-07001

PD-L1 Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is Q9NZQ7-1.

PD-L1 Protein, Human, Recombinant (His), PE-Labeled

产品编号 TMPY-07001

PD-L1 Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is Q9NZQ7-1.

规格	价格	库存	数量
25 tests	¥ 2,930	期货
100 tests	¥ 9,870	期货

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产品信息

生物活性	Flow cytometric analysis of anti-PD-L1 CAR expression. 293 cells were lentivirally transduced with anti-PD-L1 CAR. Flow cytometric analysis was performed with a negative control protein and PD-L1 Protein, Human, Recombinant (His), PE-Labeled (Cat#TMPY-07001), respectively. Non-transduced 293 cells were used as a control (left).
产品描述	PD-L1 Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is Q9NZQ7-1.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q9NZQ7-1
别名	PD-L1,PDL1,PDCD1LG1,PDCD1L1,hPD-L1,B7-H1,B7H1,B7-H
蛋白构建	A DNA sequence encoding the Human CD274 (NP_054862.1) (Met1-Thr239) was expressed with a polyhistidine tag at the C-terminus. The protein is site-specifically labeled with PE (Excitation = 495-566 nm, Emission Max. = 575 nm).
分子量	28.8 kDa (predicted)
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method
缓冲液	This product is Lyophilized from sterile PBS, pH 7.4, with 5 %-8 % trehalose and 0.2% BSA. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
复溶方法	Please refer to the lot-specific COA.
存储	Twelve months from date of receipt at -20℃ to -70℃ in lyophilized form and 3 months at -70℃ under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Blockade: Blocking AntibodiImmune Checkpoint Blockade: PD-L1 / B7-H1 / CImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyPD-L1 / B7-H1 / CD274 Immune Checkpoint ProteTargeted Therapy

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