MMP2-IN-1

Name: MMP2-IN-1
Brand: TargetMol
SKU: T60845
Rating: 4.5 (1 reviews)

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产品编号 T60845Cas号 2764598-01-6

MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡，在部分癌细胞中显示出显着的抗增殖活性。MMP2-IN-1 是MMP2 的中度强效抑制剂 (IC50 = 6.8 μM)。

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MMP2-IN-1

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产品编号 T60845Cas号 2764598-01-6

MMP2-IN-1 通过阻滞细胞周期和诱导细胞凋亡，在部分癌细胞中显示出显着的抗增殖活性。MMP2-IN-1 是MMP2 的中度强效抑制剂 (IC50 = 6.8 μM)。

规格	价格	库存
2 mg	¥ 987	5日内发货
5 mg	¥ 1,980	5日内发货
25 mg	¥ 6,740	6-8周
50 mg	¥ 8,760	6-8周
100 mg	¥ 13,500	6-8周

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生物活性

产品描述	MMP2-IN-1 shows siganificant antiproliferative activity in certain cancer cells through arresting the cell cycle and inducing apoptosis. MMP2-IN-1 is a moderate potenet inhibitor of MMP2 (IC 50 = 6.8 μM)[1].
体外活性	MMP2-IN-1 (compound 4a) (0-10 μM; 74 hours) exhibits IC 50 values of 0.07 μM, 0.11 μM, and 0.18 μM against MDA-MB-231, A549, and HeLa cancer cells, respectively, and over 10 μM in Hep 5G cells [1]. MMP2-IN-1 (10 μM; 24 hours) induces cell cycle arrest in the S phase [1]. MMP2-IN-1 (0.01 μM, 0.1 μM, 1 μM and 10 μM; 24 hours) induces a dose-dependent increment in early-and late-stage apoptosis of MDA-MB-231 cells, and increased the early-stage apoptosis percentage from 4.66% to 10.9% at 10 μM [1]. Cell Proliferation Assay Cell Line: MDA-MB-231, A549, HeLa and Hep 5G cells [1] Concentration: 0-10 μM Incubation Time: 74 hours Result: Exhibited IC 50 values of 0.07 μM, 0.11 μM, and 0.18 μM against MDA-MB-231, A549, and HeLa cancer cells, respectively, and over 10 μM in Hep 5G cells. Cell Cycle Analysis Cell Line: MDA-MB-231 [1] Concentration: 10 μM Incubation Time: 24 hours Result: Induced cell cycle arrest in the S phase. Apoptosis Analysis Cell Line: MDA-MB-231 [1] Concentration: 0.01 μM, 0.1 μM, 1 μM and 10 μM Incubation Time: 24 hours Result: Induced a dose-dependent increment in early-and late-stage apoptosis of MDA-MB-231 cells, and increased the early-stage apoptosis percentage from 4.66% to 10.9% at 10 μM.
体内活性	MMP2-IN-1 (100 mg/kg, 150 mg/kg, 200 mg/kg, 250 mg/kg; IP, single) causes 0%, 30%, 50% and 60% mortality rate at dosing 100 mg/kg, 150 mg/kg, 200 mg/kg and 250 mg/kg respectively [1]. MMP2-IN-1 (10 mg/kg; IP, daily, for 14 days) significantly inhibits tumor growth in metastatic 4T1 murine breast cancer model [1]. Animal Model: Kunming mice (n = 10, half male and half female) [1] Dosage: 100 mg/kg, 150 mg/kg, 200 mg/kg, 250 mg/kg Administration: IP, single Result: No mortality occurred after administration of 100 mg/kg, and the mortality rate was 30%, 50% and 60% at dosing 150 mg/kg, 200 mg/kg, 250 mg/kg respectively. Animal Model: Orthotopic 4T1 tumor-bearing mice [1] Dosage: 10 mg/kg Administration: IP, daily, for 14 days Result: Significantly inhibited tumor growth in metastatic 4T1 murine breast cancer model.