(Z)-4EGI-1

Name: (Z)-4EGI-1
Brand: TargetMol
SKU: T37099
Rating: 4.5 (1 reviews)

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产品编号 T37099Cas号 901787-88-0

(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2].

(Z)-4EGI-1

还可以

产品编号 T37099Cas号 901787-88-0

规格	价格	库存
2 mg	¥ 1,170	5日内发货
5 mg	¥ 1,980	5日内发货
25 mg	¥ 5,970	6-8周
50 mg	¥ 7,920	6-8周
100 mg	¥ 12,000	6-8周
1 mL x 10 mM (in DMSO)	¥ 2,280	5日内发货

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产品介绍

生物活性

产品描述	(Z)-4EGI-1, the Z-isomer of 4EGI-1, serves as an inhibitor of both the eIF4E/eIF4G interaction and translation initiation. It effectively binds to eIF4E, exhibiting an IC50 of 43.5 μM and a Kd value of 8.74 μM. Notably, (Z)-4EGI-1 possesses anticancer activity[1][2].
靶点活性	eIF4E:43.5 μM (IC50), eIF4E:8.74 μM (Kd)

化学信息

分子量	451.28
分子式	C₁₈H₁₂Cl₂N₄O₄S
CAS No.	901787-88-0

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 50 mg/mL (110.80 mM), Sonication and heating to 60℃ are recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2159 mL	11.0796 mL	22.1592 mL	110.7960 mL
5 mM	0.4432 mL	2.2159 mL	4.4318 mL	22.1592 mL
10 mM	0.2216 mL	1.1080 mL	2.2159 mL	11.0796 mL
20 mM	0.1108 mL	0.5540 mL	1.1080 mL	5.5398 mL
50 mM	0.0443 mL	0.2216 mL	0.4432 mL	2.2159 mL
100 mM	0.0222 mL	0.1108 mL	0.2216 mL	1.1080 mL