Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secretion, causes gallbladder contractions and relaxes the sphincter of Oddi, thereby facilitating bile drainage into the duodenum. Sincalide ammonium promotes bile secretion, contraction of the gallbladder and relaxation of the sphincter of Oddi, thereby facilitating the drainage of bile into the duodenum.Sincalide ammonium can be injected to promote gallbladder contraction, and is commonly used as an adjunct in the diagnosis of gallbladder and pancreatic diseases and in cholecystography.

Sincalide ammonium（亦称为胆囊收缩素八肽铵或CCK-8铵）作为一种新型心血管激素，在非梗塞区域的心肌纤维化有显著的抑制效果。Sincalide ammonium还在抗炎、抗凋亡和胶原沉积方面发挥积极作用。在H9c2心肌母细胞的背景下，CCK-8（铵）通过激活CCK1受体和磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/Akt）信号通路，部分抵抗由Ang II引起的细胞凋亡。

在大鼠心肌梗死(MI)模型中，Sincalide ammonium（又称胆囊收缩素八肽ammonium或CCK-8 ammonium）可缓解非梗死区域的纤维化。此外，Sincalide ammonium 还能延缓左心室重塑和MI大鼠模型中心力衰竭的进展[3]。