EGFR Protein, Human, Recombinant (His), PE-Labeled

产品编号 TMPY-06991

EGFR Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is P00533.

EGFR Protein, Human, Recombinant (His), PE-Labeled

产品编号 TMPY-06991

EGFR Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is P00533.

规格	价格	库存	数量
25 tests	¥ 2,930	期货
100 tests	¥ 9,870	期货

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产品信息

生物活性	1. Flow cytometric analysis of anti-EGFR CAR expression. 293 cells were lentivirally transduced with anti-EGFR CAR. Flow cytometric analysis was performed with a negative control protein and EGFR Protein, Human, Recombinant (His), PE-Labeled (Cat#TMPY-06991), respectively. Non-transduced 293 cells were used as a control (left). 2. Binding activity of PE-conjugated EGFR protein to PBMC cells. PBMC cells were stained with anti-CD3 antibody and EGFR Protein, Human, Recombinant (His), PE-Labeled (Cat#TMPY-06991) and detected by flow cytometry. PBMC cells stained with anti-CD3 antibody were used as a control (left).
产品描述	EGFR Protein, Human, Recombinant (His), PE-Labeled is expressed in HEK293 Cells. The accession number is P00533.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P00533
别名	PIG61,NISBD2,mENA,HER1,ERRP,ERBB1,ERBB
蛋白构建	A DNA sequence encoding the Human EGFR (NP_005219.2) (Met1-Ser645) was expressed with a polyhistidine tag at the C-terminus. The protein is site-specifically labeled with PE (Excitation = 495-566 nm, Emission Max. = 575 nm).
分子量	72 kDa (predicted)
内毒素	< 1.0 EU per μg of the protein as determined by the LAL method
缓冲液	This product is Lyophilized from sterile PBS, 0.2% BSA, pH 7.4. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
复溶方法	Please refer to the lot-specific COA.
存储	Twelve months from date of receipt at -20℃ to -70℃ in lyophilized form and 3 months at -70℃ under sterile conditions after reconstitution. Protect from prolonged exposure to light and avoid repeated freeze-thaw cycles.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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