LRP-5 Protein, Human, Recombinant (hFc)

产品编号 TMPK-00739

A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.

LRP-5 Protein, Human, Recombinant (hFc)

产品编号 TMPK-00739

规格	价格	库存
100 μg	¥ 3,100	5日内发货
500 μg	¥ 12,400	5日内发货
1 mg	¥ 20,700	5日内发货

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产品信息

生物活性	1. Immobilized Human DKK1, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Human LPR-5, hFc Tag with the EC50 of 1.04μg/ml determined by ELISA. 2. Human LRP-5, hFc Tag captured on CM5 Chip via Protein A can bind Human DKK1, His Tag with an affinity constant of 0.28 μM as determined in SPR assay.
产品描述	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.
种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	O75197-1
别名	VBCH2,OPTA1,OPS,OPPG,LRP-7,LRP7,LRP-5,LRP5,LR3VBCH2,LR3,HBM,EVR4,EVR1,BMND1OPTA1,BMND1
蛋白构建	Glu644-Gln1263
蛋白纯度	> 95% as determined by Tris-Bis PAGE
分子量	96.51 kDa (predicted). Due to glycosylation, the protein migrates to 100-115 kDa based on Tris-Bis PAGE result.
内毒素	< 1 EU/μg by the LAL method.
缓冲液	Supplied as 0.22 μm filtered solution in PBS, 100 mM L-arginine (pH 7.4).
存储	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis.