PSI-7409 tetrasodium

Name: PSI-7409 tetrasodium
Brand: TargetMol
SKU: T13852
Rating: 4.5 (1 reviews)

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产品编号 T13852Cas号 1621884-22-7

PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977)(IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively).

PSI-7409 tetrasodium

还可以

产品编号 T13852Cas号 1621884-22-7

PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977)(IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively).

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	PSI-7409 tetrasodium, the active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), exhibits specific inhibitory activity against NS5B polymerases of various genotypes, with IC50s being 1.6 μM for GT 1b_Con1, 2.8 μM for GT 2a_JFH1, 0.7 μM for GT 3a, and 2.6 μM for GT 4a, respectively.
靶点活性	GT2a JFH1:2.8 μM , GT3a:0.7 μM , GT4a:2.6 μM , GT1b Con1:1.6 μM
体外活性	The active triphosphate, PSI-7409, inhibited recombinant NS5B polymerases from genotypes 1 to 4 with comparable 50% inhibitory concentrations.?PSI-7409 also lacked any significant activity against cellular DNA and RNA polymerases.?No cytotoxicity, mitochondrial toxicity, or bone marrow toxicity was associated with PSI-7851 at the highest concentration tested (100 microM)[1].

化学信息

分子量	592.117
分子式	C₁₀H₁₆FN₂Na₄O₁₄P₃
CAS No.	1621884-22-7
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 125 mg/mL (211.11 mM)

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	1.6889 mL	8.4443 mL	16.8886 mL	84.4428 mL
5 mM	0.3378 mL	1.6889 mL	3.3777 mL	16.8886 mL
10 mM	0.1689 mL	0.8444 mL	1.6889 mL	8.4443 mL
20 mM	0.0844 mL	0.4222 mL	0.8444 mL	4.2221 mL
50 mM	0.0338 mL	0.1689 mL	0.3378 mL	1.6889 mL
100 mM	0.0169 mL	0.0844 mL	0.1689 mL	0.8444 mL