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Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc)

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产品编号 TMPH-03625

Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.9 kDa and the accession number is P68410.

Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc)

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产品编号 TMPH-03625

规格	价格	库存
5 μg	¥ 1,090	20日内发货
10 μg	¥ 1,850	20日内发货
20 μg	¥ 3,120	20日内发货
50 μg	¥ 5,890	20日内发货
100 μg	¥ 9,630	20日内发货
200 μg	¥ 11,800	20日内发货
500 μg	¥ 15,500	20日内发货
1 mg	¥ 19,200	20日内发货

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品信息

生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.9 kDa and the accession number is P68410.
种属	Tityus serrulatus
表达系统	Baculovirus Insect Cells
标签	N-10xHis, C-Myc
蛋白编号	P68410
别名	TsTX-III,TsTX III-8,Toxin T1-IV,Tityustoxin II (Toxin II;TsTX-II;Tst2),P-Mice-beta* NaTx5.1,Alpha-mammal toxin Ts2
氨基酸序列	KEGYAMDHEGCKFSCFIRPAGFCDGYCKTHLKASSGYCAWPACYCYGVPDHIKVWDYATNKC
蛋白构建	1-62 aa
蛋白纯度	> 85% as determined by SDS-PAGE.
分子量	10.9 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Tris-based buffer, 50% glycerol
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin acts on Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.5/SCN5A, Nav1.6/SCN8A and Nav1.7/SCN9A voltage-gated sodium channels, with the highest affinity for Nav1.3/SCN3A, followed by Nav1.6/SCN8A and Nav1.7/SCN9A which are affected almost equally. Interestingly, shows a significant shift of the voltage dependence of activation for Nav1.3/SCN3A that is characteristic of beta-toxins. In addition, in presence of LPS, this toxin inhibits the release of NO, IL-6 and TNF-alpha in J774.1 cells. Further, in the absence of LPS, it stimulates the production of the anti-inflammatory cytokine IL-10. This toxin is active on mammals.