CCR6 Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is P51684.

Human

HEK293 Cells

STRL22,GPR-CY4,GPRCY4,GPR29,DRY-6,DRY6,DCR2,CMKBR6,CKR-L3,CKRL3,CD196,CCR-6,CC-CKR-6,C-C CKR-6,BN-1

A DNA sequence encoding the Human CCR6 (P51684) (Met1-Met374) was expressed with a flag tag at the N-terminus.

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Chemokine receptors CCR6 and CCR7 have been reported to play important roles in T cell migration and organ-specific metastasis of various tumors. The expression levels of CCR6 and CCR7 in tumor tissues in patients with lymph node metastases than those without lymph node metastases. CCR6 and CCR7 expressions were also detected in metastatic lymph nodes. CCR6(+) subset of CD4(+) regulatory T cells, a newly characterized subset of Tregs, has been reported to contribute to local immune inhibition. There is a new subset of tumor-resident Tregs, CCR6(+) Tregs, may be dominantly responsible for the immunosuppression in tumor immunity and a potential predictor of the poor prognosis of breast cancer.