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GAD65 Protein, Mouse, Recombinant

产品编号 TMPY-03515

别名: glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa), Gad-2, GAD(65), GAD65, 6330404F12Rik

GAD65 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 65.4 kDa and the accession number is P48320.

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GAD65 Protein, Mouse, Recombinant

规格	价格/CNY		货期	数量
20 μg	￥ 2,530		5日内发货

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生物活性	Testing in progress
产品描述	GAD65 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 65.4 kDa and the accession number is P48320.

种属	Mouse
表达系统	Baculovirus Insect Cells
标签	Tag Free
蛋白编号	P48320
别名	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa), Gad-2, GAD(65), GAD65, 6330404F12Rik
蛋白构建	The Mouse GAD2 (NP_032104.2) (Met 1-Leu 585) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	65.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl, 10% gly, 3 mM DTT, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Glutamate decarboxylase 2, also known as glutamate decarboxylase 65 kDa isoform, 65 kDa glutamic acid decarboxylase, GAD2 and GAD65, is a member of thegroup II decarboxylase family. GAD2 is identified as a major autoantigen in insulin-dependent diabetes. GAD2 is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. GAD2 may also play a role in the stiff man syndrome. GAD2 is implicated in the formation of the gamma-aminobutyric acid (GABA), a neurotransmitter involved in the regulation of food intake. GABA is synthesized in brain by two isoforms of glutamic acid decarboxylase (Gad), GAD1 and GAD2. GAD1 provides most of the GABA in brain, but GAD2 can be rapidly activated in times of high GABA demand. Mice lacking GAD2 are viable whereas deletion of GAD1 is lethal. Deletion of GAD2 increased ethanol palatability and intake and slightly reduced the severity of ethanol-induced withdrawal.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Karlsen A.E., et al.,(1991), Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10. Proc. Natl. Acad. Sci. U.S.A. 88:8337-8341. 2. Bu D.-F., et al., (1992), Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.Proc. Natl. Acad. Sci. U.S.A. 89:2115-2119. 3. Bu D.-F., et al.,(1994), The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD.Genomics 21:222-228.

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Keywords

GAD65 Protein, Mouse, Recombinant glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) Gad-2 GAD(65) GAD65 pancreatic islets and brain, 65kDa glutamate decarboxylase 2 GAD 65 6330404F12Rik GAD-65 recombinant recombinant-proteins proteins protein

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