CD20 Protein, Human, Recombinant (TrxA), Biotinylated

产品编号 TMPY-05271

CD20 Protein, Human, Recombinant (TrxA), Biotinylated is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.

CD20 Protein, Human, Recombinant (TrxA), Biotinylated

产品编号 TMPY-05271

CD20 Protein, Human, Recombinant (TrxA), Biotinylated is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.

规格	价格	库存
20 μg	¥ 2,430	现货
100 μg	¥ 5,830	5日内发货
200 μg	¥ 9,950	5日内发货
500 μg	¥ 20,110	5日内发货

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产品信息

生物活性	1.Using the Octet RED System, the affinity constant (Kd) of CD20 Protein, Human, Recombinant (TrxA Tag), Biotinylated bound Mabthera was 0.04 μM. 2.Loaded Anti-Human CD20 antibody, human IgG1 on ProA Biosensor, can bind Recombinant Human CD20 Protein, TrxA Tag, Biotinylated with an affinity constant of 14.6 nM as determined in BLI assay (Routinely tested).
产品描述	CD20 Protein, Human, Recombinant (TrxA), Biotinylated is expressed in E. coli expression system with TrxA tag. The predicted molecular weight is 23.9 kDa and the accession number is A0A024R507.
种属	Human
表达系统	E. coli
标签	N-TrxA
蛋白编号	P11836
别名	S7,MS4A2,MS4A1,membrane-spanning 4-domains, subfamily A, member 1,LEU-16,CVID5,CD20,Bp35,B1
蛋白构建	A DNA sequence encoding the human MS4A1 (NP_068769.2) (Ile141-Ser188) was expressed with a TrxA tag at the N-terminus. The purified protein was biotinylated in vitro. Predicted N terminal: Met
蛋白纯度	> 80 % as determined by SDS-PAGE.
分子量	23.9 kDa (predicted)
内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed in all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells are usually in the normal range but can be very low.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy