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UNI418是一种具备抗SARS-CoV-2病毒活性的PIKfyve和PIP5K1C双抑制剂,其EC50值为1.4 μM。该化合物通过抑制PIP5K1C (IC50为60.1 nM; Kd为61 nM)来阻断ace2介导的病毒内吞作用。同时,UNI418抑制了由PIKfyve调控 (Kd为0.78 nM),关键于SARS-CoV-2病毒进入宿主细胞的蛋白酶的蛋白水解活化。
UNI418是一种具备抗SARS-CoV-2病毒活性的PIKfyve和PIP5K1C双抑制剂,其EC50值为1.4 μM。该化合物通过抑制PIP5K1C (IC50为60.1 nM; Kd为61 nM)来阻断ace2介导的病毒内吞作用。同时,UNI418抑制了由PIKfyve调控 (Kd为0.78 nM),关键于SARS-CoV-2病毒进入宿主细胞的蛋白酶的蛋白水解活化。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM). |
分子量 | 364.4 |
分子式 | C22H16N6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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