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Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。
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Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 293 | 现货 | |
2 mg | ¥ 425 | 现货 | |
5 mg | ¥ 659 | 现货 | |
10 mg | ¥ 956 | 现货 | |
25 mg | ¥ 2,160 | 现货 | |
50 mg | ¥ 2,790 | 现货 | |
100 mg | ¥ 4,150 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 728 | 现货 |
产品描述 | Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ elevation and caspase-3 activity, and improvement of mitochondrial energy metabolism.8-O-Acetylshanzhiside methylester can increase angiogenesis and improve functional recovery after stroke.8-O-Acetylshanzhiside methylester has protective effects on experimental myocardial ischemia injury, the effects might be due to block of myocardial inflammatory cascades through an HMGB1-dependent NF-κB signaling pathway.8-O-Acetylshanzhiside methylester protects diabetic brain against I/R injury by alleviating diabetic cerebral I/R injury and attenuating blood–brain barrier (BBB) breakdown, and its protective effects may involve HMGB-1 and NF-κB signalling pathway. |
别名 | ND01, 8-O-乙酰山栀苷甲酯, 8-O-Acetylshanzhiside methyl ester |
分子量 | 448.42 |
分子式 | C19H28O12 |
CAS No. | 57420-46-9 |
Smiles | COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H]2[C@@H]1[C@H](O)C[C@]2(C)OC(C)=O |
密度 | 1.52 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 82 mg/mL (182.9 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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