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Leukotriene A4 Hydrolase Protein, Human, Recombinant (His)

产品编号 TMPY-00877

别名: LAT4, leukotriene A4 hydrolase

Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is A0A140VK27.

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Leukotriene A4 Hydrolase Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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参考文献

生物活性	Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin(R-AMC). The specific activity is > 15 pmoles/min/μg.
产品描述	Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is A0A140VK27.

种属	Human
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	A0A140VK27
别名	LAT4, leukotriene A4 hydrolase
蛋白构建	Human LTA4H (NP_000886.1) (Met1-Asp611)
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	70.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H, and LTA4, is a cytoplasm protein that belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may, in turn, be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the pro-inflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

参考文献

1. Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71. 2. Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73. 3. Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82. 4. Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.

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Keywords

Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) LAT-4 LAT 4 LAT4 leukotriene A4 hydrolase recombinant recombinant-proteins proteins protein

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