UZH1a

Name: UZH1a
Brand: TargetMol
SKU: T37448
Rating: 4.5 (1 reviews)

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产品编号 T37448Cas号 2813577-78-3

UZH1a is a potent and selective inhibitor of METTL3, exhibiting an IC50 of 280 nM. It serves as a tool for epitranscriptomic modulation of cellular processes and possesses antitumor activity. Additionally, UZH1a functions as a chemical probe for the study of METTL3[1].

UZH1a

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产品编号 T37448Cas号 2813577-78-3

规格	价格	库存	数量
5 mg	¥ 6,800	期货

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产品介绍

生物活性

产品描述

体外活性

UZH1a (2.5-160 μM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 11 μM, 67 μM, and 87 μM, respectively[1].UZH1a (2.5-100 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13 cells in a dose-dependent manner (IC50=4.6 μM)[1].UZH1a (40 μM; 16 h) reduces m6A methylation level in mRNA from MOLM-13, HEK293T, and U2Os cells[1].UZH1a (20 μM; 16 h) increases apoptosis and leads to cell cycle arrest in MOLM-13 cells[1].

化学信息

分子量	558.71
分子式	C₃₂H₄₂N₆O₃
CAS No.	2813577-78-3
密度	1.234 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 80 mg/mL (143.19 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7898 mL	8.9492 mL	17.8984 mL	89.4919 mL
5 mM	0.3580 mL	1.7898 mL	3.5797 mL	17.8984 mL
10 mM	0.1790 mL	0.8949 mL	1.7898 mL	8.9492 mL
20 mM	0.0895 mL	0.4475 mL	0.8949 mL	4.4746 mL
50 mM	0.0358 mL	0.1790 mL	0.3580 mL	1.7898 mL
100 mM	0.0179 mL	0.0895 mL	0.1790 mL	0.8949 mL