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SLAMF6 Protein, Human, Recombinant

产品编号 TMPY-03804

SLAMF6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.9 kDa and the accession number is Q96DU3-1.

SLAMF6 Protein, Human, Recombinant

SLAMF6 Protein, Human, Recombinant

产品编号 TMPY-03804
SLAMF6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.9 kDa and the accession number is Q96DU3-1.
规格价格库存数量
100 μg¥ 3,8205日内发货
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产品信息

生物活性
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述
SLAMF6 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.9 kDa and the accession number is Q96DU3-1.
种属
Human
表达系统
HEK293 Cells
标签Tag Free
蛋白编号Q96DU3-1
别名
SLAM family member 6,SF2000,NTB-A,NTBA,Ly108,KALIb,KALI,CD352
蛋白构建
A DNA sequence encoding the human SLAMF6 (Q96DU3-1)(Met1-Met226) was expressed with six amino acids (LEVLFQ) at the C-terminus. Predicted N terminal: Gln 22
蛋白纯度
> 95 % as determined by SDS-PAGE
分子量23.9 kDa (predicted); 37-43 kDa (reducing conditions)
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法
A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice.
研究背景
SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly18, is a single-pass type I membrane protein that belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly18 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly18 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly18 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly18 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly18 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

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