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TargetMol | Compound Library

抗纤维化化合物库现货

Anti-Fibrosis Compound Library

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产品编号 L9810

纤维化(fibrosis)是一种病理改变,主要表现为器官组织内纤维结缔组织增多,实质细胞减少,持续进展可致器官结构破坏和功能减退,乃至衰竭,严重威胁人类健康和生命。纤维化可发生于多种器官,常见的包括肺脏、肝脏、肾脏、骨髓等。纤维化通常由各种刺激导致的慢性炎症性反应引起,包括:持续性感染,自身免疫反应,过敏性反应,化学刺激,射线和组织损伤等。 TargetMol 抗纤维化化合物库收集了1800 种潜在的抗纤维化分子,包括相关靶点如TGFβ、TNFα、MMP 的抑制剂、抗氧化剂及抗炎分子等,是研究纤维化机制和开发抗纤维化药物的良好工具。

TargetMol 的所有产品和服务仅用于科学研究,不能被用于人体,我们也不向个人提供产品和服务。

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产品编号 L9810

抗纤维化化合物库

规格

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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产品特性 产品特性

  • 1800种潜在的抗纤维化分子,是研究纤维化的有效工具,可以用于高通量筛选和高内涵筛选;
  • 靶点包括TGFβ、TNFα、MMP、EGFR、NADPH-oxidase等;
  • 部分化合物已经得到FDA批准上市;?
  • 详细的说明书,化合物结构、靶点信息、IC50值、活性描述等;
  • NMR、HPLC/LCMS等多种检测技术保证产品结构正确,纯度高,减少假阳性。

Packaging And Storage | TargetMol 包装和储存

  • 可选用DMSO耐受的96/384孔板或2D 条形码编码管;
  • 干粉蓝冰运输,DMSO溶液干冰运输;
  • 排布:96孔板:1st & 12th 空白对照,384孔板:1st & 2nd & 23th & 24th空白对照。

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Library Customization | TargetMol 化合物库组成

Apoptosis
Autophagy
PI3K
VEGFR
PDGFR
COX
mTOR
Raf
Wnt/beta-catenin
c-Kit
Reactive Oxygen Species
MMP
TGF-beta/Smad
GSK-3
CDK
NF-κB
FGFR
p38 MAPK
FLT
Ras
ERK
Akt
AMPK
Src
MEK
IκB/IKK
DNA-PK
CFTR
MAPK
TNF
JNK
EGFR
ALK
ATM/ATR
S6 Kinase
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Aurora Kinase
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c-RET
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TOPK
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Drug Metabolite
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Smo
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Epigenetic Reader Domain
Porcupine
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Ephrin Receptor
ASK
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LPA Receptor
ribosome
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TAM Receptor
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Discoidin Domain Receptor (DDR)
NADPH-oxidase
BMI-1
cholecystokinin
Tyrosinase
Microtubule Associated
Thrombin
PD-1/PD-L1
NO Synthase

Keywords