Antitubercular agent-27

Name: Antitubercular agent-27
Brand: TargetMol
SKU: T61141
Price: 1070 USD
Availability: InStock
Rating: 4.5 (1 reviews)

还可以

产品编号 T61141Cas号 2460651-09-4

Antitubercular agent-27 (compound 1) 是一种有效的抗结核药剂，IC50值为 3.2 μM，MICb> 值为 7.8 μM，IC90值为 7.0 μM。Antitubercular agent-27 对结核分枝杆菌 H37Rv 的耐药分离株显示出抗分枝杆菌活性。Antitubercular agent-27 显示出有效的细胞内抗分枝杆菌活性和低细胞毒性。

Antitubercular agent-27

还可以

产品编号 T61141Cas号 2460651-09-4

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述

Antitubercular agent-27 (compound 1) exhibits potent antitubercular properties, demonstrated by an IC50 of 3.2 μM, an MIC of 7.8 μM, and an IC90 of 7.0 μM. It effectively targets resistant Mycobacterium tuberculosis H37Rv isolates, displaying significant intracellular antimycobacterial activity with low cytotoxicity [1].

体外活性

Antitubercular agent-27 (compound 1) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC 50 s of 2.4, 100, 120, 1.3, 3.1 μM, MICs of 3.2, 140, 160, 2.4, 4.2 μM, IC 90 s of 3.0, 120, 142, 2.2, 3.5 μM for FQ-R1, INH-R1, INH-R2, RIF-R1, RIF-R2, respectively [1]. Antitubercular agent-27 (0-200 μM) shows antibacterial activity with an MIC value of 0.80 μM, IC 50 value of 0.23 μM, and IC 90 value of 0.43 μM in low oxygen condition, and an MIC value of 0.45 μM, IC 50 value of 0.27 μM, and IC 90 value of 0.35 μM in normal oxygen condition [1]. Antitubercular agent-27 (0-200 μM) shows intracellular activity with an IC 50 value of 1.45 μM, and IC 90 value of 1.61 μM, and low cytotoxicity with an IC 50 value of >100 μM [1].