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BI-2563是一种小分子化合物,具有潜在的抗肿瘤活性。BI 2536与Polo-like kinase 1 (Plk1)结合并抑制其活性,导致易受影响的肿瘤细胞群体发生有丝分裂停滞、细胞分裂过程中断和细胞凋亡。Plk1是一种丝氨酸/苏氨酸-蛋白激酶,是控制多个对有丝分裂和细胞分裂至关重要的过程的关键调节因子。
BI-2563是一种小分子化合物,具有潜在的抗肿瘤活性。BI 2536与Polo-like kinase 1 (Plk1)结合并抑制其活性,导致易受影响的肿瘤细胞群体发生有丝分裂停滞、细胞分裂过程中断和细胞凋亡。Plk1是一种丝氨酸/苏氨酸-蛋白激酶,是控制多个对有丝分裂和细胞分裂至关重要的过程的关键调节因子。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | BI-2563 is a small molecule compound with potential antitumor properties. It binds to Polo-like kinase 1 (Plk1) and inhibits its activity, resulting in mitotic arrest, interruption of cell division, and apoptosis in susceptible tumor cell populations. Plk1 is a serine/threonine-protein kinase that serves as a key regulator of several critical processes essential for mitosis and cytokinesis. |
别名 | BI-2536, BI2536, BI 2536 |
分子量 | 539.67 |
分子式 | C28H41N7O4 |
CAS No. | 876126-71-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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