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FAM3D Protein, Human, Recombinant (His)

产品编号 TMPY-02042

别名: OIT1, family with sequence similarity 3 member D, EF7, UNQ567/PRO1130

FAM3D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is Q96BQ1-1.

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FAM3D Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 2,940		5日内发货

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生物活性	Testing in progress
产品描述	FAM3D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.4 kDa and the accession number is Q96BQ1-1.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q96BQ1-1
别名	OIT1, family with sequence similarity 3 member D, EF7, UNQ567/PRO1130
蛋白构建	The Human FAM3D (Q96BQ1-1) (Met 1-Phe 224) was fused with a polyhistidine tag at the C-terminus
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	23.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Family with sequence similarity 3 (FAM3) family is a novel cytokine-like gene family, which has four genes in this family, FAM3A, FAM3B, FAM3C, and FAM3D, each encoding a protein (224-235 amino acids) with a hydrophobic leader sequence. It had indicated that FAM3B/PANDER (pancreatic derived factor) is highly expressed in pancreas, and FAM3A and FAM3C in almost all tissues. FAM3D is abundantly expressed in placenta and weakly expressed in small intestine. Immunohistochemistry showed that FAM3A is expressed prominently in the vascular endothelium, particularly capillaries. FAM3A and FAM3B protein were both localized to the islets of Langerhans of the endocrine pancreas. Recombinant FAM3B protein has delayed effects on beta-cell function. FAM3C is involved in retinal laminar formation processes in vertebrates. NFATC2, SCP2, CACNA1C, TCRA, POLE, and FAM3D, were associated with narcolepsy. Some of these associations were further supported by gene expression analyses and an association study in essential hypersomnia (EHS), CNS hypersonia similar to narcolepsy.

参考文献

1. Zhu Y,et al.(2002) Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics. 80(2): 144-50. 2. Katahira T,et al.(2010) Secreted factor FAM3C (ILEI) is involved in retinal laminar formation. Biochem Biophys Res Commun. 392(3): 301-6. 3. Shimada M,et al.(2010) An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Hum Genet. 128(4): 433-41.

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Keywords

FAM3D Protein, Human, Recombinant (His) OIT1 UNQ567/PRO-1130 OIT 1 family with sequence similarity 3 member D EF7 UNQ567/PRO 1130 UNQ567/PRO1130 OIT-1 EF 7 EF-7 recombinant recombinant-proteins proteins protein

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