G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide. G907 inhibits E. coli MsbA with an IC50 value of 18 nM.

MsbA:18 nM

G907 inhibits the activity of purified Escherichia coli MsbA with an IC50 value of 18 nM over a concentration range of 0.1 nM to 100 μM[1]. G907 exhibits allosteric inhibitory activity against MsbA[2]. At 100 nM, G907 completely inhibits the transport activity of biotin-PE in liposomes containing MsbA-WT protein[1].