Naratriptan hydrochloride

产品编号 T6602Cas号 143388-64-1

别名 盐酸那拉曲坦|||Naratriptan HCl|||Amerge|||Naramig|||GR-85548A hydrochloride

Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂，有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用，从而减少促炎神经肽的释放。

Naratriptan hydrochloride

产品编号 T6602别名 盐酸那拉曲坦, Naratriptan HCl, Amerge, Naramig, GR-85548A hydrochlorideCas号 143388-64-1

规格	价格	库存
1 mg	¥ 163	现货
2 mg	¥ 223	现货
5 mg	¥ 359	现货
10 mg	¥ 578	现货
25 mg	¥ 813	现货
50 mg	¥ 1,180	现货
100 mg	¥ 1,690	现货
200 mg	¥ 2,530	现货
500 mg	¥ 3,970	现货
1 mL x 10 mM (in DMSO)	¥ 577	现货

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产品介绍

生物活性

产品描述

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydrochloride) binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.

别名

盐酸那拉曲坦, Naratriptan HCl, Amerge, Naramig, GR-85548A hydrochloride

化学信息

分子量	371.93
分子式	C₁₇H₂₅N₃O₂S·HCl
CAS No.	143388-64-1

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: 20 mg/mL (53.8 mM)

DMSO: 65 mg/mL (174.76 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6887 mL	13.4434 mL	26.8868 mL	134.4339 mL
5 mM	0.5377 mL	2.6887 mL	5.3774 mL	26.8868 mL
10 mM	0.2689 mL	1.3443 mL	2.6887 mL	13.4434 mL
20 mM	0.1344 mL	0.6722 mL	1.3443 mL	6.7217 mL
50 mM	0.0538 mL	0.2689 mL	0.5377 mL	2.6887 mL