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14-3-3 sigma Protein, Human, Recombinant (GST)

产品编号 TMPY-01263

别名: 14-3-3 σ, stratifin, YWHAS

14-3-3 sigma Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 50.1 kDa and the accession number is P31947-1.

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14-3-3 sigma Protein, Human, Recombinant (GST)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	14-3-3 sigma Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 50.1 kDa and the accession number is P31947-1.

种属	Human
表达系统	E. coli
标签	N-GST
蛋白编号	P31947-1
别名	14-3-3 σ, stratifin, YWHAS
蛋白构建	The Human SFN (NP_006133.1) (Met 1-Ser 248) was fused with the GST tag at the N-terminus.
蛋白纯度	> 94 % as determined by SDS-PAGE
分子量	50.1 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Supplied as sterile 20 mM Tris, 150 mM NaCl, 10 mM GSH, 25% glycerol, pH 8.0.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathways. More than 1 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

参考文献

1. Zakut-Houri R.,et al.,(1985), Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4:1251-1255. 2. Lamb P.,et al., (1986), Characterization of the human p53 gene.Mol. Cell. Biol. 6:1379-1385. 3. Harlow E.,et al.,(1985), Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.Mol. Cell. Biol. 5:1601-1610.

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Keywords

14-3-3 sigma Protein, Human, Recombinant (GST) 14-3-3 σ stratifin YWHAS recombinant recombinant-proteins proteins protein

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