hCAI/II-IN-4

Name: hCAI/II-IN-4
Brand: TargetMol
SKU: T61635
Rating: 4.5 (1 reviews)

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产品编号 T61635Cas号 2480284-01-1

hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. Additionally, hCAI/II-IN-4 exhibits anti-hypoxia properties while maintaining low toxicity. This compound is suitable for investigating acute mountain sickness (AMS) in research studies [1].

hCAI/II-IN-4

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产品编号 T61635Cas号 2480284-01-1

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品描述	hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. Additionally, hCAI/II-IN-4 exhibits anti-hypoxia properties while maintaining low toxicity. This compound is suitable for investigating acute mountain sickness (AMS) in research studies [1].
体外活性	hCAI/II-IN-4 (compound 6d) (5-200μM; 48 hours) has no apparent cytotoxicity in HEK293 cells [1]. Cell Cytotoxicity Assay [1] Cell Line: HEK293 cells Concentration: 5, 25, 50, 100 and 200 μM Incubation Time: 48 hours Result: The cell viability rate was higher than 60%.
体内活性	hCAI/II-IN-4 (compound 6d) (400-2000 mg/kg; p.o.; Male BLAB/c mice of hypoxia) has no apparent toxic effect in vivo [1]. Animal Model: Male BLAB/c mice of hypoxia [1] Dosage: 400, 500 and 2000 mg/kg Administration: Oral administration Result: Prolonged the survival time of mice by 29.3% compared with that of the blank control group.