Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
KKL-10 是一种核糖体拯救抑制剂,对细菌具有广谱抗菌活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 445 | 现货 | ||
5 mg | ¥ 997 | 现货 | ||
10 mg | ¥ 1,720 | 现货 | ||
25 mg | ¥ 3,290 | 现货 | ||
50 mg | ¥ 4,880 | 现货 | ||
100 mg | ¥ 6,960 | 现货 |
产品描述 | KKL-10, a ribosome rescue inhibitor, has broad-spectrum antimicrobial activity against bacteria. |
体外活性 | KKL-10 shows markedly antimicrobial activity against both fully and attenuated virulent strains of F. tularensis. The MIC against F. tularensis strain Schu S4 and LVS are 0.48 and 0.12 μg/mL, respectively. KKL-10 inhibits the intracellular growth of F. tularensis during all stages of infection. KKL-10 cannot affect macrophage function or viability. KKL-10 (17.5 μg/mL) produces cytotoxic effects of less than 5%. The combination of IFN-γ stimulation and KKL-10 can reduce the bacterial load by >99.9%. KKL-10 also inhibits the growth of F. tularensis inside eukaryotic cells and exhibits no toxicity to HepG2 cells. |
别名 | KKL 10 |
分子量 | 364.22 |
分子式 | C14H10BrN3O2S |
CAS No. | 952849-76-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
DMSO: 6.8 mg/mL (18.67 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7456 mL | 13.728 mL | 27.4559 mL | 68.6398 mL |
5 mM | 0.5491 mL | 2.7456 mL | 5.4912 mL | 13.728 mL | |
10 mM | 0.2746 mL | 1.3728 mL | 2.7456 mL | 6.864 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
KKL-10 952849-76-2 Microbiology/Virology ribosome Antibacterial Bacterial KKL10 Inhibitor inhibit KKL 10 inhibitor