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KKL-10 是一种核糖体拯救抑制剂,对细菌具有广谱抗菌活性。
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KKL-10 是一种核糖体拯救抑制剂,对细菌具有广谱抗菌活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 445 | 现货 | |
5 mg | ¥ 997 | 现货 | |
10 mg | ¥ 1,720 | 现货 | |
25 mg | ¥ 2,920 | 现货 | |
50 mg | ¥ 4,220 | 现货 | |
100 mg | ¥ 5,990 | 现货 |
产品描述 | KKL-10, a ribosome rescue inhibitor, has broad-spectrum antimicrobial activity against bacteria. |
体外活性 | KKL-10 shows markedly antimicrobial activity against both fully and attenuated virulent strains of F. tularensis. The MIC against F. tularensis strain Schu S4 and LVS are 0.48 and 0.12 μg/mL, respectively. KKL-10 inhibits the intracellular growth of F. tularensis during all stages of infection. KKL-10 cannot affect macrophage function or viability. KKL-10 (17.5 μg/mL) produces cytotoxic effects of less than 5%. The combination of IFN-γ stimulation and KKL-10 can reduce the bacterial load by >99.9%. KKL-10 also inhibits the growth of F. tularensis inside eukaryotic cells and exhibits no toxicity to HepG2 cells. |
别名 | KKL 10 |
分子量 | 364.22 |
分子式 | C14H10BrN3O2S |
CAS No. | 952849-76-2 |
Smiles | Cc1ccc(cc1)-c1nnc(NC(=O)c2ccc(Br)s2)o1 |
密度 | 1.620 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | DMSO: 6.8 mg/mL (18.67 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
DMSO
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