Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells, reflected by an IC50 value of 1.5±0.1 μM. Exhibiting significant anti-mitotic activity, this compound demonstrates anti-tumor potential, particularly useful in glioblastoma multiforme (GBM) research [1].

Tubulin inhibitor 36（Compound 10）在多种人类肿瘤细胞系中显示出显著的抗增殖作用。对HeLa、MCF7、U87 MG、T98G、HepG2、HCT8、HT-29细胞的IC 50 值分别为0.039、0.038、0.022、0.025、0.037、0.040、0.059 μM [1]。此外，在HeLa、MCF7和U87 MG细胞中，100 nM浓度的Tubulin inhibitor 36经过24小时、48小时及72小时的处理，能有效地阻止有丝分裂并诱导细胞凋亡 [1]。