购物车
- 全部删除
- 您的购物车当前为空
HPK1-IN-54 (Compound 16) 是一种有效的HPK1 (造血祖细胞激酶 1) 抑制剂,通过抑制HPK1活性提升T细胞的激活和增殖,发挥抗肿瘤作用。其对HPK1的IC50为2.67 nM,并显示出对MAP4K家族(>100倍)及其他选定激酶(>300倍)的高选择性。在小鼠和大鼠中,HPK1-IN-54呈现出中等的体内清除率和合理的口服暴露度。在CT26小鼠结肠癌模型中,该化合物表现出良好的抗肿瘤效果,并且与抗PD-1联合使用时展现协同作用。HPK1-IN-54 有望在免疫研究领域中发挥作用。
HPK1-IN-54 (Compound 16) 是一种有效的HPK1 (造血祖细胞激酶 1) 抑制剂,通过抑制HPK1活性提升T细胞的激活和增殖,发挥抗肿瘤作用。其对HPK1的IC50为2.67 nM,并显示出对MAP4K家族(>100倍)及其他选定激酶(>300倍)的高选择性。在小鼠和大鼠中,HPK1-IN-54呈现出中等的体内清除率和合理的口服暴露度。在CT26小鼠结肠癌模型中,该化合物表现出良好的抗肿瘤效果,并且与抗PD-1联合使用时展现协同作用。HPK1-IN-54 有望在免疫研究领域中发挥作用。
产品描述 | HPK1-IN-54 (Compound 16) is a potent inhibitor of HPK1 (hematopoietic progenitor kinase 1), enhancing T cell activation and proliferation by blocking HPK1 activity to exert antitumor effects. It has an IC50 of 2.67 nM for HPK1, showing excellent selectivity over the MAP4K family (>100-fold) and other selected kinases (>300-fold). HPK1-IN-54 exhibits moderate in vivo clearance and reasonable oral exposure in both mice and rats. Additionally, in the CT26 mouse colon cancer model, HPK1-IN-54 demonstrates significant antitumor activity and shows a synergistic effect when combined with anti-PD-1 therapy. HPK1-IN-54 holds promise for research in the field of immunology. |
分子量 | 583.66 |
分子式 | C32H34FN7O3 |
CAS No. | 3048537-48-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
评论内容