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Antibacterial agent 122 (compound 15) 是一种硫脲衍生物,可用于研究结核病。Antibacterial agent 122 表现出低细胞毒性,并且具有抗分枝杆菌活性。
Antibacterial agent 122 (compound 15) 是一种硫脲衍生物,可用于研究结核病。Antibacterial agent 122 表现出低细胞毒性,并且具有抗分枝杆菌活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | |
50 mg | ¥ 13,800 | 6-8周 | |
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Antibacterial agent 122 (compound 15) is a thiourea derivative that can be used in the studies of tuberculosis. Antibacterial agent 122 shows low cytotoxicity as well as anti-mycobacterial activity [1]. |
体外活性 | Antibacterial agent 122 (compound 15) (25-200 μM, 24 h) inhibits M. tuberculosis H37Rv with the MIC 50 value of 5.9 μM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC 50 value of 8.1μM [1]. Antibacterial agent 122 (compound 15) (25-200 μM) acts on NO scavenging with an IC 50 value of 184.2 μM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 μM [1]. Antibacterial agent 122 (compound 15) (0-200 μM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC 50 values of 28.4 μM and 47.9 μM, respectively [1]. Antibacterial agent 122 (compound 15) (25-100 μM, 4 days) inhibits M. tuberculosis M299 with an MIC 50 value of 24.7 μM [1]. |
分子量 | 302.35 |
分子式 | C15H14N2O3S |
CAS No. | 109310-99-8 |
存储 | Shipping with blue ice. |
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