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Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。
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Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 387 | 现货 | |
10 mg | ¥ 555 | 现货 | |
25 mg | ¥ 877 | 现货 | |
100 mg | ¥ 1,978 | 现货 | |
200 mg | ¥ 2,655 | 现货 |
产品描述 | Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity. |
靶点活性 | Mpro:0.67 μM (IC50), COVID-19 virus:4.67 μM (EC50) |
别名 | 依布硒, SPI-1005, PZ-51, CCG-39161 |
分子量 | 274.18 |
分子式 | C13H9NOSe |
CAS No. | 60940-34-3 |
Smiles | O=C1N([Se]C=2C1=CC=CC2)C3=CC=CC=C3 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mM H2O: Insoluble | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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