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ZLMT-12 (compound 35) 是他克宁衍生物,是一种有效的 CDK2 (IC50: 0.011 μM) 和 CDK9 (IC50: 0.002 μM) 抑制剂。ZLMT-12 能够较弱的抑制 AChE (IC50: 19.023 μM) 和 BuChE (IC50: 2.768 μM)。ZLMT-12 具抗增殖活性,且细胞毒性较低。ZLMT-12 能够将细胞周期阻滞在 S 期和 G2/M 期,并诱导细胞凋亡。
ZLMT-12 (compound 35) 是他克宁衍生物,是一种有效的 CDK2 (IC50: 0.011 μM) 和 CDK9 (IC50: 0.002 μM) 抑制剂。ZLMT-12 能够较弱的抑制 AChE (IC50: 19.023 μM) 和 BuChE (IC50: 2.768 μM)。ZLMT-12 具抗增殖活性,且细胞毒性较低。ZLMT-12 能够将细胞周期阻滞在 S 期和 G2/M 期,并诱导细胞凋亡。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 10-14周 | |
50 mg | ¥ 13,800 | 10-14周 | |
100 mg | ¥ 17,500 | 10-14周 |
产品描述 | ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: 0.011 μM) and CDK9 (IC50: 0.002 μM). ZLMT-12 weakly inhibits AChE (IC50: 19.023 μM) and BuChE (IC50: 2.768 μM). ZLMT-12 has anti-proliferative activity and low cytotoxicity. ZLMT-12 blocks the cell cycle in S-phase and G2/M-phase and induces apoptosis. |
分子量 | 479.02 |
分子式 | C26H31ClN6O |
存储 | Shipping with blue ice. |
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