CXCL5 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.4 kDa and the accession number is P50228.

Mouse

P. pastoris (Yeast)

Scyb6,Scyb5,LIX,GCP-2,ENA-78,chemokine (C-X-C motif) ligand 5,AMCF-II

A DNA sequence encoding the mouse Cxcl5 (NP_033167.2) (Val45-Ala118) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Val 45

> 95 % as determined by SDS-PAGE.

A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

CXCL5 is a small cytokine belonging to the CXC chemokine family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL5 is produced following stimulation of cells with the inflammatory cytokines interleukin-1 or tumor necrosis factor-alpha. It also can be detected in eosinophils, and can be inhibited with the type II interferon. CXCL5 plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which can be utilized to understand more about pain in other inflammatory conditions like arthritis and cystitis. It stimulates the chemotaxis of neutrophils possesses angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.