PKC-IN-4

Name: PKC-IN-4
Brand: TargetMol
SKU: T61604
Rating: 4.5 (1 reviews)

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产品编号 T61604Cas号 2636771-29-2

PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α. Moreover, this compound effectively impedes the permeability of the retinal vasculature, induced by both VEGF and TNFα. [1]

PKC-IN-4

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产品编号 T61604Cas号 2636771-29-2

规格	价格	库存
25 mg	¥ 14,900	6-8周
50 mg	¥ 19,420	6-8周
100 mg	¥ 24,625	6-8周

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产品描述	PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), exhibiting an IC 50 value of 0.52 μM. In vitro studies have demonstrated that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α. Moreover, this compound effectively impedes the permeability of the retinal vasculature, induced by both VEGF and TNFα. [1]
体外活性	PKC-IN-4 (compound 7l) shows VEGF - induced endothelial permeability with an EC 50 of 0.071 μM [1].
体内活性	PKC-IN-4 (10 mg/kg for i.v.; 20 mg/kg for p.o.) shows orally active with oral bioavailability of 81.7% [1]. Animal Model: Animal Model: CD-1 mice [1] Dosage: 10, 20 mg/kg Administration: 10 mg/kg for i.v.; 20 mg/kg for p.o. Result: Showed good PK parameters with oral bioavailability of 81.7%.